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Donna McEachern Selected Research

STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)

6/2021SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.
12/2019Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein.
11/2019A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.

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Donna McEachern Research Topics

Disease

38Neoplasms (Cancer)
03/2024 - 03/2008
10Leukemia
01/2021 - 10/2014
9Breast Neoplasms (Breast Cancer)
01/2023 - 05/2011
7Prostatic Neoplasms (Prostate Cancer)
03/2024 - 10/2014
3Colonic Neoplasms (Colon Cancer)
10/2014 - 06/2008
3Small Cell Lung Carcinoma (Small Cell Lung Cancer)
01/2014 - 10/2012
2Osteosarcoma (Osteogenic Sarcoma)
01/2015 - 10/2014
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2023
1B-Cell Lymphoma (Lymphoma, B Cell)
12/2022
1Hematologic Neoplasms (Hematological Malignancy)
12/2022
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
12/2022
1Multiple Myeloma
12/2022
1Waldenstrom Macroglobulinemia (Macroglobulinemia)
12/2022
1Lymphoma (Lymphomas)
01/2020
1Triple Negative Breast Neoplasms
01/2017
1Ovarian Neoplasms (Ovarian Cancer)
03/2012
1Head and Neck Neoplasms (Head and Neck Cancer)
04/2011
1Squamous Cell Carcinoma of Head and Neck
04/2011

Drug/Important Bio-Agent (IBA)

26Proteins (Proteins, Gene)FDA Link
03/2024 - 04/2011
11snake venom protein C activatorIBA
03/2024 - 08/2018
6Androgen Receptors (Androgen Receptor)IBA
03/2024 - 10/2020
5Inhibitor of Apoptosis ProteinsIBA
09/2013 - 11/2008
4Proteolysis Targeting ChimeraIBA
01/2023 - 08/2018
4SAR405838IBA
12/2016 - 10/2014
4SM 164IBA
03/2012 - 11/2008
3enzalutamideIBA
03/2024 - 10/2020
3STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
06/2021 - 11/2019
2Estrogen ReceptorsIBA
01/2023 - 12/2016
2CaspasesIBA
12/2022 - 04/2011
2indoleIBA
01/2018 - 11/2017
2Oncogene Proteins (Oncogene Protein)IBA
10/2014 - 06/2008
2N- benzhydryl- 5- (2- (methylamino)propanamido)- 3- (3- methylbutanoyl)- 6- oxodecahydropyrrolo(1,2- a)(1,5)diazocine- 8- carboxamideIBA
09/2013 - 04/2011
1CCS1477IBA
03/2024
1LisaftoclaxIBA
12/2022
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
12/2022
1Cysteine (L-Cysteine)FDA Link
01/2021
1Anaplastic Lymphoma KinaseIBA
11/2020
1ARD-61IBA
10/2020
1Transcription Factors (Transcription Factor)IBA
12/2019
1Proto-Oncogene Proteins c-mdm2IBA
01/2019
1pyrazoleIBA
01/2018
1quinolineIBA
11/2017
1Fulvestrant (Faslodex)FDA Link
12/2016
1Estradiol (Delestrogen)FDA LinkGeneric
12/2016
1navitoclaxIBA
06/2015
1ABT-737IBA
06/2015
1BM-1197IBA
01/2014
1Biomarkers (Surrogate Marker)IBA
09/2013
1Caspase 8 (Caspase-8)IBA
09/2013
1compound 30IBA
10/2012
1BM-957IBA
10/2012
1GSK 1363089IBA
03/2012
1CrizotinibIBA
03/2012
1tyrosine receptor (receptor, tyrosine)IBA
03/2012
1Tyrosine Kinase InhibitorsIBA
03/2012
1Membrane Proteins (Integral Membrane Proteins)IBA
03/2012
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
03/2012
1Phosphotransferases (Kinase)IBA
03/2012
1Radiation-Sensitizing AgentsIBA
04/2011
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
11/2008
12-oxindole (oxindole)IBA
06/2008
1MI-219IBA
03/2008

Therapy/Procedure

10Oral Administration
03/2024 - 07/2013
7Therapeutics
03/2024 - 09/2013
1Castration
03/2024
1Transplantation
09/2013